Generic name: Alfuzosin hydrochloride

What is UroXatral?

UroXatral (alfuzosin) is an alpha-blocker. It works by relaxing muscles in the prostate and bladder neck, making it easier to urinate.

UroXatral is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate.

Alfuzosin may also be used for purposes not listed in this medication guide.

UroXatral

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

swelling in your ankles or feet;

shortness of breath; or

chest pain.

Stop using UroXatral and call your doctor at once if you have:

a prolonged erection (lasting longer than 4 hours); or

severe dizziness, fainting, fast or pounding heartbeats.

Common UroXatral side effects may include: mild dizziness;; headache;; stuffy nose;; tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Health Benefits

UroXatral can improve your urine flow and decrease how often you have to urinate during the day. This may help you reduce your risk of urinary retention (a condition in which you are unable to empty your bladder).

Alfuzosin can also help relieve some of the symptoms of BPH, such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently.

Dosage

Your dosage of UroXatral will be based on your medical condition and response to treatment. Follow your doctor’s instructions carefully.

The usual starting dose is 10 mg once daily. If this does not provide enough symptom relief, your doctor may increase the dose to 20 mg once daily.

UroXatral should be taken at the same time each day.

To take UroXatral extended-release tablets:

Swallow the tablet whole with a full glass of water. Do not split, chew, or crush it.

If you have difficulty swallowing the tablet whole, you may dissolve the tablet in 1 ounce (30 milliliters) of water. This will form a solution that can be swallowed easily. Drink all of the mixture right away. Then add an additional 2 ounces (60 milliliters) of water to the same glass, swirl gently and drink right away to make sure you consume the entire dose.

Interactions

Uroxatral may interact with other medications. Tell your doctor all prescriptions and over the counter medications you use. Especially tell your doctor if you take:

warfarin (Coumadin, Jantoven);

a diuretic or “water pill”;

insulin or oral diabetes medication;

drugs that make you feel dizzy or sleepy; or

an antibiotic–clarithromycin, erythromycin, telithromycin.

This list is not complete and many other drugs may affect Uroxatral. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Mechanism of Action

UroXatral works by relaxing the smooth muscle in the prostate and bladder neck. This helps to improve urine flow and relieve some of the symptoms of BPH, such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently.

Alfuzosin may also help reduce your risk of urinary retention (a condition in which you are unable to empty your bladder) and the need for surgery to treat BPH.

Alfuzosin belongs to a class of drugs called alpha-blockers. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Pharmacokinetics

Alfuzosin is rapidly absorbed following oral administration with maximum plasma concentrations occurring within 1 to 2 hours. The mean bioavailability of an immediate release 10 mg tablet is 64%.

Alfuzosin is 96% bound to plasma proteins. The apparent volume of distribution following intravenous administration is 21 L.

Metabolism and Excretion

Alfuzosin is extensively metabolized in the liver by CYP3A4 via oxidation to the active metabolite, 6-hydroxyalfuzosin, and via N-dealkylation, followed by conjugation. 6-Hydroxyalfuzosin has pharmacologic activity similar to that of alfuzosin. Both alfuzosin and 6-hydroxyalfuzosin are eliminated primarily in the urine.

Half-life

The mean elimination half-lives of alfuzosin and 6-hydroxyalfuzosin following multiple doses of 10 mg alfuzosin extended-release tablets are 11.6 hours and 12.4 hours, respectively.