PDR Health

Tylenol with Codeine

What is Tylenol with Codeine?

Tylenol with Codeine is a pain reliever that contains both acetaminophen and codeine. It is used to relieve moderate to severe pain.

Tylenol with Codeine

Health Benefits

Tylenol with Codeine can be used to relieve pain from a variety of conditions, including:




-Menstrual cramps

-Muscle aches and pains

Side Effects

Some common side effects of Tylenol with Codeine include:


-Nausea and vomiting


Taking Tylenol with Codeine may also cause more serious side effects, such as:

-Allergic reactions (rash, hives, difficulty breathing)

-Severe liver damage (yellowing of the skin or eyes, dark urine, abdominal pain)

If you experience any of these serious side effects, stop taking Tylenol with Codeine and seek medical help immediately.


Tylenol with Codeine is available in tablet and liquid form. The usual adult dose is 1 or 2 tablets every 4 to 6 hours as needed for pain relief.

If you have liver disease, your doctor may recommend a lower dose of Tylenol with Codeine.

Pregnant women should not take Tylenol with Codeine as it can be harmful to the developing baby.


Tylenol with Codeine may interact with other medications, such as:

-Blood thinners (warfarin)

-MAO inhibitors (isocarboxazid, phenelzine, tranylcypromine)

-SSRIs (fluoxetine, paroxetine)

Taking Tylenol with Codeine with these medications may increase the risk of bleeding. Be sure to tell your doctor about all the medications you are taking before taking Tylenol with Codeine.

Tylenol with Codeine should not be taken with alcohol as it can increase the risk of liver damage.

Mechanism of Action

Tylenol with Codeine works by blocking pain signals from the brain and by decreasing the amount of pain-relieving chemicals (endorphins) in the body. Codeine also decreases the activity of the digestive system, which can lead to constipation.

Acetaminophen works by relieving pain and reducing fever. It does this by increasing the production of prostaglandins, which are hormones that help control pain and inflammation.


Tylenol with Codeine is absorbed from the gastrointestinal tract and enters the bloodstream. It then bind to proteins in the blood and is distributed to different tissues in the body.

Codeine is metabolized by the liver and broken down into its active form, morphine. Morphine then binds to opioid receptors in the brain and spinal cord, which leads to pain relief.

Acetaminophen is also metabolized by the liver and broken down into its active form, paracetamol. Paracetamol works by inhibiting the production of prostaglandins, which helps to reduce pain and inflammation.


The half-life of Tylenol with Codeine is 3-4 hours.


Tylenol with Codeine can be habit-forming and should be used only by the person it was prescribed for. Misuse of Tylenol with Codeine can lead to addiction, overdose, and death.

Alternatives to Tylenol with Codeine

There are many alternative medications to Tylenol with Codeine, such as:

-Ibuprofen (Advil)

-Naproxen (Aleve)

-Acetaminophen (Tylenol)


These medications can be used to relieve pain from a variety of conditions. Be sure to speak with your doctor before taking any over-the-counter medications.

Is Aspirin more effective than Tylenol with Codeine?

There is no definitive answer as to whether Aspirin or Tylenol with Codeine is more effective. Both medications can be used to relieve pain from a variety of conditions. However, Aspirin may be more effective for headaches, while Tylenol with Codeine may be more effective for muscle aches and pains. Speak with your doctor about which medication is right for you.