What is Trifluoperazine hydrochloride?

Trifluoperazine is an antipsychotic medicine. It works by changing the activity of certain chemicals in the brain.

This medicine is available only with your doctor’s prescription.

This product is available in the following dosage forms:

Tablet, Extended Release

Capsule, Extended Release

Trifluoperazine hydrochloride

Health Benefits

Trifluoperazine hydrochloride is used to treat the following conditions:

Schizophrenia

Anxiety

Agitation

Tourette’s syndrome

Side Effects

Common side effects of Trifluoperazine hydrochloride include:

Drowsiness

Dizziness

Restlessness

Blurred vision

Dry mouth

Weight gain

Less common side effects of Trifluoperazine hydrochloride can include:

Constipation

Diarrhea

Nausea and vomiting

Rash

Changes in blood pressure

Severe side effects of Trifluoperazine hydrochloride can include:

Tardive dyskinesia

Neuroleptic malignant syndrome (NMS)

Seizures

Yellowing of the skin or eyes (jaundice)

Trifluoperazine hydrochloride can also cause a decrease in white blood cells, which can lead to serious infections.

Dosage

The usual starting dose of Trifluoperazine hydrochloride for adults is 10 mg to 15 mg daily. The dose may be increased by 5 mg to 10 mg every three to four days until the desired effect is achieved. The maximum recommended dose is 40 mg per day.

For children ages 6 to 12, the starting dose is 2.5 mg to 5 mg daily. The dose may be increased by 2.5 mg to 5 mg every three to four days as needed. The maximum recommended dose is 20 mg per day.

For children ages 3 to 6, the starting dose is 1 mg daily. The dose may be increased by 0.5 mg every three to four days as needed. The maximum recommended dose is 5 mg per day.

This medicine should be taken with food or milk to avoid stomach upset.

Interactions

Trifluoperazine hydrochloride can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Mechanism of Action

Trifluoperazine hydrochloride works by blocking dopamine receptors in the brain. Dopamine is a neurotransmitter that helps regulate mood, appetite, and other functions. By blocking dopamine receptors, trifluoperazine hydrochloride can help to improve symptoms of schizophrenia and other mental disorders.

Pharmacokinetics

Trifluoperazine hydrochloride is absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. The bioavailability of trifluoperazine hydrochloride is about 50%. Peak plasma concentrations are reached within 3 to 4 hours after oral administration.

The half-life of trifluoperazine hydrochloride is about 24 hours. Trifluoperazine hydrochloride is metabolized in the liver and excreted in the urine.

Alternatives to Trifluoperazine hydrochloride

There are many alternatives to trifluoperazine hydrochloride. Some common ones include:

Aripiprazole (Abilify)

Haloperidol (Haldol)

Olanzapine (Zyprexa)

Risperidone (Risperdal)

Ziprasidone (Geodon)

These drugs work in a similar way to trifluoperazine hydrochloride and can be used to treat the same conditions. Talk to your doctor about which drug is best for you.

Is Olanzapine more effective than Trifluoperazine hydrochloride?

There is no definitive answer to this question as each drug works differently for each person. Olanzapine may be more effective for some people, while trifluoperazine hydrochloride may be more effective for others. Talk to your doctor about which drug is best for you.

How long does it take to work?

It may take several weeks for trifluoperazine hydrochloride to start working. You may not notice the full effects of the drug until it has been taken for several weeks. Do not stop taking trifluoperazine hydrochloride without talking to your doctor, even if you don’t feel it is working.