Generic name: Nateglinide

What is Starlix?

Starlix (nateglinide) is an oral diabetes medicine that helps control blood sugar levels by stimulating the body to produce insulin.

Starlix

Health Benefits

Starlix can be used to help control blood sugar levels in adults with type 2 diabetes. It works by increasing the amount of insulin produced by the pancreas.

Side Effects

The most common side effects of Starlix include:

Headache

Dizziness

Nausea

Diarrhea

Stomach pain

If you experience any of these side effects, contact your doctor immediately. You should also contact your doctor if you experience any serious side effects, such as:

Allergic reaction (difficulty breathing; hives; swelling of the face, lips, tongue, or throat)

Low blood sugar (headache, hunger, sweating, irritability, dizziness, fast heartbeat, feeling jittery or shaking)

High blood sugar (increased urination; excessive thirst; dry mouth; fruity breath odor)

Starlix is a prescription medicine used to control blood sugar levels in adults with type 2 diabetes. It is not for people with type 1 diabetes or people with diabetic ketoacidosis (increased ketones in the blood or urine).

Dosage

The usual starting dose of Starlix is 60 mg taken three times daily before each meal.

If you have kidney disease, your doctor may start you on a lower dose or monitor your kidney function more closely.

Interactions

Starlix can interact with other diabetes medicines, as well as with:

Insulin

Blood pressure medicines

ACE inhibitors

Beta blockers

Diuretics (water pills)

Be sure to tell your doctor about all the medications you take, including over-the-counter drugs, vitamins, and herbal supplements. Taking Starlix with certain other drugs may affect how well they work or increase your risk for serious side effects. Your doctor will tell you if it is safe to take Starlix with other medications.

Mechanism of Action

Starlix works by increasing the amount of insulin produced by the pancreas.

This helps to control blood sugar levels in adults with type 2 diabetes.

Pharmacokinetics

Starlix is rapidly absorbed from the gastrointestinal tract.

It reaches peak concentrations in about 1 hour.

The half-life of Starlix is 2-3 hours.

Pregnancy and breastfeeding

Starlix should not be used during pregnancy unless the potential benefit outweighs the potential risk to the fetus. If you become pregnant while taking this medicine, tell your doctor immediately.

It is not known whether Starlix passes into breast milk or if it could harm a nursing baby. You should not breastfeed while taking this medicine.

Alternatives to Starlix

There are many other drugs available to treat type 2 diabetes. Some may be a better fit for you than others.

Other drugs include:

Metformin

Sulfonylureas

Thiazolidinediones

Dipeptidyl peptidase-4 (DPP-4) inhibitors

Alpha-glucosidase inhibitors

Bile acid sequestrants

Meglitinides

SGLT2 inhibitors

Speak with your doctor about which medication may be the best for you. this is not all of the drugs available to treat type 2 diabetes. Your doctor can tell you about other options that may work well for you.