What is Phosphatidylserine?

Phosphatidylserine (PS) is a natural phospholipid that is essential for the proper function of cell membranes. It is found in high concentrations in the brain, where it plays an important role in cognitive function.

PS has been shown to improve memory and cognitive function in healthy adults as well as those with age-related cognitive decline. It may also help reduce stress and anxiety, and enhance mood and sleep quality.

How does Phosphatidylserine work?

PS is thought to work by improving communication between cells in the brain. This may help to preserve cognitive function and prevent age-related decline. PS may also help to reduce stress and anxiety by reducing the activity of stress hormones in the brain.

What is the evidence for Phosphatidylserine?

PS has been studied extensively in clinical trials and has been shown to improve memory, cognitive function, and mood in healthy adults as well as those with age-related cognitive decline.

A large, well-designed study found that PS supplementation improved memory, attention, and language skills in healthy older adults. Other studies have found that PS may help to preserve cognitive function in those with Alzheimer’s disease and other forms of dementia.

PS may also help to reduce stress and anxiety. One study found that PS supplementation reduced stress hormone levels and improved mood in healthy adults under stressful conditions. Another study found that PS may help to improve sleep quality in people with insomnia.

Side Effects

PS is generally well-tolerated and has few side effects. The most common side effect is gastrointestinal upset, such as diarrhea, nausea, and vomiting.

PS is considered safe for most adults. However, it should be used with caution in those who are taking blood thinners or other medications that affect blood clotting, as PS may increase the risk of bleeding.

It is also important to note that some forms of PS are derived from soybeans, so those with allergies to soy should avoid supplementation.

Dosages

The typical dose of PS is 100-200 mg per day. Higher doses may be used in some cases, but it is best to speak with a healthcare provider before starting supplementation.

Pharmacokinetics

PS is rapidly absorbed from the gut and enters the bloodstream. It crosses the blood-brain barrier and accumulates in the brain, where it exerts its effects. PS is metabolized by the liver and excreted in the urine.

Long-term effects

PS is considered safe for long-term use. However, more research is needed to determine the safety and efficacy of long-term supplementation.

Pregnancy and breastfeeding

PS is not recommended for pregnant or breastfeeding women due to a lack of safety data.

Where can I get Phosphatidylserine?

Phosphatidylserine is available as a dietary supplement from many online and brick-and-mortar retailers. It can also be found in some foods, such as soybeans, fish, and beef.

How do I take Phosphatidylserine?

The typical dose of PS is 100-200 mg per day. Higher doses may be used in some cases, but it is best to speak with a healthcare provider before starting supplementation. PS is best taken with food.

What form(s) does Phosphatidylserine come in?

PS is available in capsules, tablets, powders, and liquids.

What can I expect from Phosphatidylserine?

PS has been shown to improve memory and cognitive function in healthy adults as well as those with age-related cognitive decline. It may also help reduce stress and anxiety, and enhance mood and sleep quality.

Alternatives for Phosphatidylserine

N-Acetylcysteine, omega-3 fatty acids, and ginkgo biloba are all nutritional supplements that have been shown to improve cognitive function. Speak with a healthcare provider to determine which supplement is right for you.

Is N-Acetylcysteine more effective?

N-Acetylcysteine has been shown to be more effective than PS in improving cognitive function in those with Alzheimer’s disease. However, more research is needed to determine whether it is more effective than PS in healthy adults or those with age-related cognitive decline.

Is Omega-3 Fatty Acids more effective?

Omega-3 fatty acids have been shown to be more effective than PS in improving cognitive function in those with Alzheimer’s disease. However, more research is needed to determine whether it is more effective than PS in healthy adults or those with age-related cognitive decline.

Is Ginkgo Biloba more effective?

Ginkgo biloba has been shown to be more effective than PS in improving cognitive function in those with Alzheimer’s disease. However, more research is needed to determine whether it is more effective than PS in healthy adults or those with age-related cognitive decline.