Generic name: Famotidine
Other brand names: Pepcid AC, Pepcid RPD

What is Pepcid?

Pepcid is a histamine-2 blocker that decreases the amount of acid produced in the stomach. It is used to treat and prevent heartburn and other symptoms caused by too much acid in the stomach.

Pepcid is also used to treat ulcers in the duodenum (the first part of the small intestine) and preventing their recurrence. It is also used to treat gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

Pepcid

Health Benefits

Pepcid is used to treat and prevent heartburn and other symptoms caused by too much acid in the stomach. It is also used to treat ulcers in the duodenum (the first part of the small intestine) and preventing their recurrence. Pepcid is also used to treat gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

Pepcid is also effective in treating Zollinger-Ellison syndrome, a condition characterized by the overproduction of stomach acid.

Pepcid may also be used to decrease the amount of acid produced in the stomach in preparation for surgery or endoscopy.

Side Effects and precautions

Pepcid is generally well-tolerated, with the most common side effects being headache and constipation. Less common side effects include diarrhea, dizziness, and fatigue.

Pepcid should be used with caution in people with liver disease or kidney disease. It should also be used with caution in people who are taking other medications that can affect the liver or kidney.

Pepcid should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pepcid should be used during breastfeeding only if the potential benefit justifies the potential risk to the infant.

Dosage and Administration

Pepcid is available in tablet, orally disintegrating tablet, capsule, and suspension form. It is typically taken once or twice a day with or without food.

Tablets and capsules should be swallowed whole with a glass of water. The suspension can be taken with or without food. If you are taking the suspension, shake the bottle well before each dose.

Pepcid should be taken at least 30 minutes before a meal to be effective. To prevent heartburn, take Pepcid no more than 30 minutes after eating a meal or drinking a beverage that causes heartburn.

To treat ulcers, Pepcid may be taken for up to 8 weeks. To prevent ulcers, Pepcid may be taken for up to 12 months.

To treat GERD, Pepcid may be taken for 4-8 weeks. To prevent GERD, Pepcid may be taken for up to 6 months.

Pepcid should be taken as directed by your doctor. Do not take more or less than the recommended dose. Do not skip doses or stop taking Pepcid without first talking to your doctor.

If you miss a dose of Pepcid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once

Interactions

Pepcid may interact with other medications. Tell your doctor all prescription and over-the-counter medications and supplements you take. Pepcid should not be taken within 2 hours of taking antacids or H2 blockers.

Pepcid may also interact with blood thinners, cholesterol-lowering drugs, HIV/AIDS medications, methotrexate, and seizure medications. These interactions can increase your risk of side effects or make the medications less effective.

Before taking Pepcid, tell your doctor about all your medical conditions and allergies. Pepcid should be used with caution in people with liver disease or kidney disease.

Pepcid should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pepcid should be used during breastfeeding only if the potential benefit justifies the potential risk to the infant.

Mechanism of Action

Pepcid works by reducing the amount of acid produced in the stomach. It does this by inhibiting the action of histamine, a substance that is responsible for stimulating acid production.

Pepcid is an H2 blocker. H2 blockers work by blocking the action of histamine at histamine receptor sites on cells in the stomach, which prevents histamine from stimulating acid production.

Pharmacokinetics

Pepcid is rapidly absorbed from the gastrointestinal tract and reaches peak levels in about 1-2 hours. The half-life of Pepcid is 3-6 hours.

Pepcid is metabolized in the liver and excreted in the urine.