What is Orudis?

Orudis (ketoprofen) is a nonsteroidal anti-inflammatory drug (NSAID). Ketoprofen works by reducing hormones that cause inflammation and pain in the body.

Orudis is used to relieve pain from various conditions such as headache, dental pain, menstrual cramps, muscle aches, or arthritis. It is also used to reduce fever. Orudis may also be used for purposes not listed in this medication guide.

Health Benefits

Orudis offers several health benefits.

-Reduces pain from various conditions such as headache, dental pain, menstrual cramps, muscle aches, or arthritis

-Reduces fever

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

shortness of breath (even with mild exertion);

chest pain, weakness, and irregular heartbeats;

swelling in your hands, ankles, or feet;

high blood pressure–severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath;;

liver problems–nausea , upper stomach pain (that may spread to your back), itching, loss of appetite , dark urine , clay-colored stools , jaundice (yellowing of the skin or eyes);

kidney problems–little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

low red blood cells (anemia)–pale skin , unusual weakness, feeling light-headed or short of breath, rapid heart rate , increased thirst and urination;;

serious skin reaction–fever, sore throat , swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Dosage

The usual adult dose is 50 mg two or three times daily. The maximum recommended dose is 200 mg daily.

Interactions

Orudis may interact with other drugs.Tell your doctor all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Mechanism of Action

The exact mechanism of action of Orudis is unknown. It is thought to work by inhibiting the synthesis of prostaglandins, which are chemicals that play a role in pain and inflammation.

Pharmacokinetics

Orudis is rapidly absorbed from the gastrointestinal tract. The bioavailability of Orudis is approximately 50%. The peak plasma concentration is reached within 1-2 hours. Ketoprofen is 97% bound to plasma proteins.

Half-life

The elimination half-life of ketoprofen ranges from 4 to 6 hours.

Metabolism

Ketoprofen is metabolized in the liver by cytochrome P450 enzymes, specifically by CYP2C9. The primary metabolites are hydroxyketoprofen, ketoprofen glucuronide, and 5-hydroxyketoprofen glucuronide.

Excretion

Ketoprofen and its metabolites are excreted mainly in the urine. Less than 2% of the dose is excreted in the feces.

Alternatives to Orudis

There are many alternative NSAIDs available. Some examples include:

Aspirin

Ibuprofen (Advil, Motrin)

Naproxen (Aleve)

Celecoxib (Celebrex)

Diclofenac (Voltaren)

Indomethacin (Indocin)

Meloxicam (Mobic)

Piroxicam (Feldene)

Is Naxproxen more effective than Orudis?

There is no definitive answer to this question as different people may respond differently to different NSAIDs. Some people may find that one NSAID works better for them than another, while others may not notice a difference. It is generally recommended that people try different NSAIDs to see which one works best for them.