What is Namenda?

Namenda (memantine) is an oral medication used to treat moderate to severe Alzheimer’s disease. It works by reducing the activity of chemicals in the brain that may contribute to the symptoms of Alzheimer’s disease.

Health Benefits

Namenda has been shown to improve cognitive function, including memory, attention, and language. It may also help with the ability to perform daily activities.

In clinical studies, Namenda was effective in slowing the progression of Alzheimer’s disease. Namenda may be used alone or in combination with other Alzheimer’s medications.

Risks and Side Effects

The most common side effects of Namenda include headache, dizziness, and confusion. Other potential side effects include nausea, vomiting, constipation, and fatigue.

Namenda can cause serious side effects in some people. These include allergic reactions, seizures, and liver problems. Call your doctor right away if you experience any of these side effects.

Namenda can interact with other medications. Be sure to tell your doctor about all the medications you take, including over-the-counter drugs and supplements.

Dosages

Namenda is available in tablet and oral solution form. The usual starting dose is 5 mg once daily. Your doctor may adjust your dose based on your response to the medication.

Take Namenda exactly as prescribed by your doctor. Do not take more or less than directed.

If you miss a dose of Namenda, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule.

Interactions

Namenda can interact with other medications. Be sure to tell your doctor about all the medications you take, including over-the-counter drugs and supplements.

Namenda may also interact with alcohol. Drinking alcohol while taking Namenda can increase your risk of side effects.

Examples of medications that can interact with Namenda include:

antidepressants

anti-anxiety medications

muscle relaxers

seizure medications

pain medications

cold or allergy medications

heart rhythm medications

Mechanism of Action

Namenda works by reducing the activity of chemicals in the brain that may contribute to the symptoms of Alzheimer’s disease. It is thought to work by blocking glutamate, a chemical messenger that plays a role in learning and memory.

Namenda is a long-acting medication. It is slowly absorbed and eliminated from the body over time. This allows it to maintain its effect throughout the day.

Pharmacokinetics

Namenda is rapidly absorbed from the gastrointestinal tract. It has a half-life of 60-80 hours, which means it remains in the body for up to four days.

Namenda is eliminated from the body through urine. Less than 1% of the drug is excreted unchanged.

Alternatives to Namenda

There are several medications that can be used to treat Alzheimer’s disease. These include cholinesterase inhibitors and memantine.

Your doctor can help you choose the best treatment option for you based on your symptoms and health condition.

Clinical Trials

Namenda has been studied in several clinical trials. These studies have shown that it is effective in slowing the progression of Alzheimer’s disease.

If you are interested in participating in a clinical trial, talk to your doctor. Clinical trials are an important step in developing new treatments for Alzheimer’s disease.

Chemistry

Namenda is a white, crystalline powder that is soluble in water.

The chemical structure of Namenda is:

Molecular formula: C13H21ClN4O2S

Molecular weight: 323.8 g/mol

Storage and Stability

Namenda should be stored at room temperature, 15-30°C (59-86°F). Keep the medication in a tight, light-resistant container. Protect it from moisture. Do not store it in the bathroom.

Keep Namenda out of the reach of children. Do not take the medication if it has expired or if it is damaged. Talk to your pharmacist about the proper disposal of expired or unused