PDR Health


What is Melatonin?

Melatonin is a hormone that is naturally produced in the body. It helps to regulate the sleep-wake cycle and is involved in the body’s natural circadian rhythm. Melatonin levels are highest at night and lowest during the day. When it is dark, the body produces more melatonin, which makes us feel sleepy. Exposure to light decreases melatonin production and makes us feel more alert. Melatonin supplements can be used to help people who have difficulty falling asleep or staying asleep.


How Does Melatonin Work?

Studies have shown that melatonin can help people fall asleep faster and stay asleep longer. It is thought to work by resetting the body’s internal clock and helping to regulate the sleep-wake cycle. Melatonin supplements are often used by people who have jet lag or work night shifts.

What are the Benefits of Melatonin?

In addition to helping people sleep, melatonin has a number of other potential health benefits. It is an antioxidant and may help to protect cells from damage. Melatonin has also been shown to boost the immune system, reduce inflammation, and improve heart health.

What Are the Side Effects of Melatonin?

Melatonin is generally safe for most people when taken in small doses for a short period of time. The most common side effect is drowsiness. Other potential side effects include headaches, nausea, and dizziness. Melatonin should not be taken with certain medications, such as blood thinners and antidepressants. It is also not recommended for people with seizure disorders or who are pregnant or breastfeeding.


Melatonin is rapidly absorbed from the gastrointestinal tract and has a bioavailability of nearly 100%. It is metabolized in the liver and excreted in the urine. The half-life of melatonin is short, ranging from 30 minutes to 3 hours.


The recommended dosage of melatonin depends on the person’s age, weight, and health condition. For most people, the recommended dose is 3-5 mg before bedtime. Higher doses may be used for certain conditions, such as jet lag or sleep disorders. Melatonin should not be taken for more than two weeks without consulting a healthcare provider.

How do you stimulate melatonin production?

There are several things you can do to stimulate melatonin production:

-Expose yourself to sunlight during the day: This helps to regulate the body’s natural circadian rhythm.

-Avoid blue light at night: Blue light from electronic devices can suppress melatonin production.

-Get enough sleep: Sleep deprivation can decrease melatonin levels.

-Eat a healthy diet: A diet high in processed foods and sugar can disrupt the body’s natural production of melatonin.

-Take a supplement: Melatonin supplements are available over the counter and can help to increase levels of this hormone.

Do not drive or operate heavy machinery after taking melatonin as it can cause drowsiness. If you are pregnant or breastfeeding, talk to your healthcare provider before taking this supplement. Melatonin is generally safe for most people, but it can interact with certain medications.

Long-term effects

There is currently no evidence to suggest that melatonin has any long-term side effects. However, it is always best to speak to a healthcare provider before taking any supplement, especially if you have a medical condition or are taking other medications.


There are a number of things you can do to improve sleep without taking supplements. These include following a healthy sleep routine, avoiding caffeine and alcohol before bedtime, and creating a relaxing environment in your bedroom. If you are still having difficulty sleeping, talk to your healthcare provider about other treatment options.


Melatonin can interact with a number of medications, including:

-Antidepressants: Melatonin can increase the effects of certain antidepressants.

-Blood thinners: Melatonin may increase the risk of bleeding when taken with blood thinners.

-Seizure disorders: Melatonin may increase the frequency of seizures in people with seizure disorders.