What is Evista?

Evista (raloxifene) is a selective estrogen receptor modulator (SERM). A SERM is a medication that acts like estrogen in some parts of the body and like anti-estrogen in other parts. Evista is used to treat osteoporosis in postmenopausal women. It works by helping to keep bones strong.

Health Benefits

There are many health benefits associated with Evista. One of the most important is that it can help to reduce the risk of osteoporosis. Osteoporosis is a condition in which bones become weak and fragile. This can lead to fractures, which can be painful and debilitating. Evista helps to keep bones strong, which can reduce the risk of fractures.

In addition to reducing the risk of osteoporosis, Evista has also been shown to reduce the risk of breast cancer. This is a very important benefit, as breast cancer is a serious disease that can be life-threatening. By reducing the risk of breast cancer, Evista can help to keep women healthy and improve their quality of life.

Side Effects

Evista is generally well-tolerated, but like all medications, it may cause side effects. The most common side effects are hot flashes and leg cramps. These side effects are usually mild and go away on their own. If they persist or are bothersome, please consult your doctor.

Less common side effects include:








If you experience any of these side effects, please consult your doctor. Some of these side effects may require medical attention.


The usual starting dose of Evista is 60 mg once daily. Your doctor may increase your dose to 120 mg once daily if needed. Evista should be taken with food.

If you miss a dose of Evista, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue on your regular dosing schedule. Do not take two doses of Evista at the same time.

Evista is available in tablets of 60 mg. It is also available as a generic medication.


Evista should not be taken with estrogen or estrogen-containing medications. These medications include birth control pills, patch, ring, and hormone replacement therapy. Taking Evista with these medications may cause serious side effects.

Evista may also interact with other medications. Be sure to tell your doctor about all the medications you are taking, including over-the-counter medications and supplements. Evista should not be taken with tamoxifen (Soltamox).

Mechanism of Action

Evista works by binding to estrogen receptors in the body. This action is different from that of other SERMs, such as tamoxifen, which bind to estrogen receptors and block their activity. The binding of Evista to estrogen receptors results in a change in the conformation (shape) of the receptor. This change leads to a decrease in the activity of the receptor.

The net effect of Evista’s binding to estrogen receptors is a reduction in estrogenic activity in the body. This can help to reduce the risk of osteoporosis and breast cancer.


Evista is well-absorbed from the gastrointestinal tract. It is metabolized in the liver and has a half-life of about 27 hours. Evista is excreted in the urine and feces.

Alternatives to Evista

There are several alternatives to Evista. These include:

Hormone replacement therapy: Hormone replacement therapy (HRT) is the most effective treatment for osteoporosis. It is also the most effective treatment for hot flashes and other menopausal symptoms. However, HRT carries an increased risk of breast cancer.

Selective estrogen receptor modulators (SERMs): SERMs are a class of medications that have both estrogenic and antiestrogenic effects. They are used to treat hot flashes and osteoporosis. SERMs include tamoxifen (Soltamox) and raloxifene (Evista).

Bisphosphonates: Bisphosphonates are a class of medications that are used to treat osteoporosis. They include alendronate (Fosamax), risedronate (Actonel), and ibandronate (Boniva).

Calcium and vitamin D: Calcium and vitamin D are essential for the prevention and treatment of osteoporosis. Calcium supplementation is recommended for all postmenopausal women. Vitamin D supplementation may also be recommended.