What is Zyloprim?

Zyloprim (allopurinol) is a xanthine oxidase inhibitor that reduces the production of uric acid in your body. Uric acid build-up can lead to gout or kidney stones. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment. Allopurinol may also be used for purposes not listed in this medication guide.

Zyloprim

Health Benefits

reduces the risk of gout

reduces the risk of kidney stones

decreases uric acid levels in people receiving cancer treatment

Side Effects

Common side effects may include:

upset stomach

diarrhea

muscle pain or weakness

joint pain

rash

headache

rare side effects may include:

severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

kidney problems — little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

liver problems — nausea, upper stomach pain (that may spread to your back), itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Dosage

The recommended starting dosage of allopurinol for people with gout is 100 mg daily. The dose may be increased by 100 mg every 2 to 4 weeks until the uric acid level becomes normal or until side effects become bothersome.

For people who are receiving cancer treatment: The starting dose of allopurinol is usually 300 mg daily. If you have kidney disease, your doctor may start you on a lower dose or a different dosing schedule.

Zyloprim Interactions

Taking Zyloprim with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking allopurinol with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with allopurinol. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using during your treatment with Zyloprim, especially:

azathioprine;

mercaptopurine;

theophylline;

cyclosporine;

blood thinners such as warfarin (Coumadin, Jantoven);

diabetes medicine you take by mouth, such as glipizide or glyburide;

a diuretic or “water pill”;

cancer medicine;

heart or blood pressure medicine;

seizure medicine; or

steroid medicine.

This list is not complete. Other drugs may interact with allopurinol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Pharmacokinetics

Zyloprim is rapidly absorbed from the gastrointestinal tract and nearly completely converted to oxipurinol (alloxanthine), its active metabolite, within one hour. The peak concentration of oxipurinol in plasma usually occurs about two hours after an oral dose of allopurinol and has a mean value of about 10 micromolar (┬ÁM).

In adults with normal renal function, between 70% and 80% of a single oral dose of allopurinol is excreted as oxypurinol in the urine within 24 hours.

Alternatives to Zyloprim

If you are looking for alternatives to Zyloprim, these drugs may be a good option:

Probenecid: Probenecid is a uricosuric medication that helps the kidney eliminate excess uric acid from the body.

Colchicine: Colchicine is a medication that helps to prevent gout attacks by reducing inflammation and swelling.

Febuxostat: Febuxostat is a xanthine oxidase inhibitor that helps to reduce uric acid levels in the blood.

Is Probenecid more effective than Zyloprim?

There is no direct comparison of the effectiveness of probenecid and allopurinol, but probenecid may be more effective in some people. Probenecid may also have fewer side effects than allopurinol.

Is Colchicine more effective than Zyloprim?

There is no direct comparison of the effectiveness of colchicine and allopurinol, but colchicine may be more effective in some people. Colchicine may also have fewer side effects than allopurinol.

Is Febuxostat more effective than Zyloprim?

There is no direct comparison of the effectiveness of febuxostat and allopurinol, but febuxostat may be more effective in some people. Febuxostat may also have fewer side effects than allopurinol.