Trazodone is a medication that is used to treat depression. It is a part of the class of medications called serotonin reuptake inhibitors (SSRIs), which work by increasing the levels of serotonin in the brain. Trazodone is available as an oral tablet, an oral extended-release tablet, and an injectable solution.

Side Effects:

The most common side effects of trazodone include drowsiness, headache, dry mouth, and dizziness. Trazodone can also cause QT prolongation, which is a rare but potentially life-threatening condition.

Drug Interactions:

Trazodone may interact with other medications such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and SSRIs. Trazodone should not be taken with alcohol or grapefruit juice.

Pregnancy and Breastfeeding:

Trazodone is classified as a category C pregnancy drug, which means it may be harmful to a developing fetus. Trazodone should only be used during pregnancy if the potential benefits outweigh the potential risks. Trazodone is not known to be harmful during breastfeeding.


The recommended starting dose of trazodone for depression is 150 mg per day. Trazodone can be taken with or without food.


Trazodone may cause low blood pressure, which can lead to fainting. Trazodone may also cause QT prolongation, which can lead to an irregular heartbeat and potentially life-threatening heart rhythm disorders. Trazodone should be used with caution in people with heart disease or other conditions that may predispose them to QT prolongation. Trazodone should also be used with caution in people with liver disease or kidney disease.