IUPAC name: 3,4′,5-trihydroxy-trans-stilbene

ChemSpider ID: 23482446

Molecular formula: C22H22O11

Molar mass: 446.39 g/mol

Appearance: white powder

Solubility in water: insoluble

Pycnogenol is a natural supplement derived from the bark of the French maritime pine tree. It is rich in procyanidins, a type of flavonoid. Pycnogenol supplements are available for purchase online and in stores. The recommended dosage of pycnogenol varies depending on the condition being treated. Side effects of pycnogenol may include nausea and upset stomach. Pycnogenol may also interact with certain medications, so be sure to speak with your healthcare provider before taking this supplement.

In general, pycnogenol is considered safe. However, as with any supplement, it’s always important to speak with your healthcare provider before beginning any new supplement regimen.

Pycnogenol is a dietary supplement derived from the bark of the French maritime pine tree. Pycnogenol is rich in procyanidins, a type of flavonoid. Flavonoids are plant-based nutrients that have powerful antioxidant effects.

Pycnogenol has been shown to offer a number of health benefits, including improved circulation, reduced inflammation, and enhanced cognitive function. Additionally, pycnogenol supplements have been shown to be effective in treating conditions like asthma, allergies, ADHD, and diabetes.

While pycnogenol is generally considered safe, it can cause some side effects like nausea and upset stomach. It is also important to note that pycnogenol may interact with certain medications, so be sure to speak with your healthcare provider before taking this supplement.

Benefits

1. Improves Circulation

2. Reduces Inflammation

3. Enhances Cognitive Function

4. Treats Asthma, Allergies, ADHD, and Diabetes

Side Effects

1. Nausea

2. Upset Stomach

Interactions

1. Pycnogenol may interact with certain medications, so be sure to speak with your healthcare provider before taking this supplement.

2. Pycnogenol is generally considered safe, but it can cause some side effects like nausea and upset stomach.

3. If you’re looking for a natural way to improve your health, pycnogenol may be worth considering. However, it’s always important to speak with your healthcare provider before beginning any new supplement regimen.

4. Pycnogenol supplements are available for purchase online and in stores.

5. Pycnogenol is a natural supplement derived from the bark of the French maritime pine tree. It is rich in procyanidins, a type of flavonoid.

Pharmacokinetics

After oral ingestion, pycnogenol is rapidly and extensively metabolized in the gut and liver into low molecular weight metabolites, including phenolic acids and their glucuronides, sulfates, and methylated derivatives. Peak plasma concentrations of these metabolites are reached within 2-4 hours post-ingestion. The pharmacokinetic profiles of pycnogenol and its metabolites differ depending on the type of formulation ingested. For example, when pycnogenol is ingested as a capsules, peak plasma concentrations of phenolic acids are achieved within 2 hours post-ingestion. However, when pycnogenol is ingested as a powder, peak plasma concentrations are not achieved until 4 hours post-ingestion.

The bioavailability of pycnogenol is variable and depends on the formulation and route of administration. For example, when pycnogenol is ingested as a capsules, the bioavailability ranges from 5-30%. However, when pycnogenol is ingested as a powder, the bioavailability is estimated to be between 50-80%.

The half-life of pycnogenol in plasma is approximately 8 hours

Elimination

Pycnogenol and its metabolites are eliminated primarily in the urine. The half-life of pycnogenol in plasma is approximately 8 hours.

Dosage

The recommended dosage of pycnogenol varies depending on the condition being treated. For example, the recommended dosage for reducing inflammation is 50-100 mg per day. For treating asthma, the recommended dosage is 200 mg per day. And for improving cognitive function, the recommended dosage is 150 mg per day.

Supplements

Pycnogenol supplements are available for purchase online and in stores.