Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinamide is also known as niacinamide or nicotinic acid amide. It is an amide of nicotinic acid (vitamin B3 / niacin).

Nicotinamide supplements are generally well tolerated. The most common side effect is mild gastrointestinal upset, which can be avoided by taking the supplement with food. Nicotinamide may also cause skin flushing in some people. This side effect is usually temporary and will go away with continued use of the supplement. Rarely, nicotinamide can cause more serious side effects such as liver damage, but this is very rare and only seen in people who are taking high doses of the supplement.

If you are considering taking a nicotinamide supplement, it is important to speak to your healthcare provider first to make sure that it is right for you.

Nicotinamide

PHARMACOKINETICS

Nicotinamide is rapidly and completely absorbed from the gastrointestinal tract after oral administration. The bioavailability of nicotinamide is 100%.

After absorption, nicotinamide is widely distributed in the body and is Excreted mainly in the urine as metabolites. The half-life of nicotinamide is 1-2 hours.

INDICATIONS

Nicotinamide supplements are commonly used to treat or prevent vitamin B3 deficiency. Nicotinamide may also be used to treat other conditions as determined by your healthcare provider.

CONTRAINDICATIONS

You should not take a nicotinamide supplement if you are allergic or hypersensitive to it. You should also avoid taking nicotinamide if you have a history of liver disease or liver problems.

If you are pregnant or breastfeeding, you should not take a nicotinamide supplement unless directed to do so by your healthcare provider.

SIDE EFFECTS

Nicotinamide supplements are generally well tolerated. The most common side effect is mild gastrointestinal upset, which can be avoided by taking the supplement with food. Nicotinamide may also cause skin flushing in some people. This side effect is usually temporary and will go away with continued use of the supplement. Rarely, nicotinamide can cause more serious side effects such as liver damage, but this is very rare and only seen in people who are taking high doses of the supplement.

If you experience any serious side effects after taking a nicotinamide supplement, you should stop taking the supplement and seek medical attention immediately.

Other potential side effects of nicotinamide include:

Nausea

Vomiting

Diarrhea

Headache

Dizziness

Rare side effects of nicotinamide may include liver damage, jaundice, and allergic reactions. If you experience any of these side effects after taking a nicotinamide supplement, stop taking the supplement and speak to your healthcare provider.

INTERACTIONS

Nicotinamide may interact with other medications, herbs, or vitamins that you are taking. It is always best to speak to your healthcare provider before starting any new supplement, especially if you are taking other medications.

Some of the potential drug interactions of nicotinamide include:

Anticoagulants (blood thinners): Nicotinamide may increase the risk of bleeding when taken with anticoagulant medications such as warfarin (Coumadin).

Medications for diabetes: Nicotinamide may increase the effects of insulin and other diabetes medications.

Medications for high cholesterol: Nicotinamide may increase the effects of cholesterol-lowering medications such as statins.

Do not take a nicotinamide supplement if you are taking any of these medications without first speaking to your healthcare provider.

You should also avoid taking nicotinamide if you have a history of liver disease or liver problems. If you are pregnant or breastfeeding, you should not take a nicotinamide supplement unless directed to do so by your healthcare provider.

BENEFITS

Nicotinamide supplements are commonly used to treat or prevent vitamin B3 deficiency. Nicotinamide may also be used to treat other conditions as determined by your healthcare provider. Some of the potential benefits of nicotinamide include:

Treating or preventing vitamin B3 deficiency

Improving cholesterol levels

Lowering blood pressure

Reducing the risk of heart disease

Protecting against age-related cognitive decline

Reducing the risk of certain types of cancer

Nicotinamide may also have other benefits not listed here. If you are considering taking a nicotinamide supplement, speak to your healthcare provider to see if it is right for you.

DOSAGE AND ADMINISTRATION

The recommended dose of nicotinamide is 500 mg per day. However, some people may need to take a higher or lower dose depending on their individual needs. Be sure to speak to your healthcare provider before taking nicotinamide to determine the best dose for you.

Nicotinamide supplements are available in capsules, tablets, powders, and liquids. The best way to take nicotinamide will depend on the form you are using. Be sure to follow the instructions on the product label or speak to your healthcare provider before taking nicotinamide. If you have any questions about how to take nicotinamide, be sure to speak to your healthcare provider.

What Is the Recommended Dosage of Nicotinamide?

The recommended dosage of nicotinamide depends on several factors, such as your age, health condition, and other medications you are taking. Always speak to your healthcare provider before starting any supplement to make sure it is safe for you and to determine the correct dosage.

The general recommended dosage of nicotinamide is 50-100 mg per day. However, your healthcare provider may recommend a different dosage depending on your individual needs.

If you are taking a nicotinamide supplement for the first time, start with a lower dose and increase gradually as tolerated. Nicotinamide supplements are available in tablet, capsule, powder, and liquid forms.

How Long Does It Take for Nicotinamide to Work?

The effects of nicotinamide vary depending on why you are taking the supplement. For example, if you are taking nicotinamide to treat vitamin B3 deficiency, you may start to feel better within a few days of starting the supplement. However, it may take several weeks for your deficiency symptoms to improve.

If you are taking a nicotinamide supplement for cholesterol or blood pressure control, it may take several weeks or months before you see any improvements.

Can I Overdose on Nicotinamide?

It is possible to overdose on nicotinamide, but this is rare and usually only seen in people who are taking very high doses of the supplement. Nicotinamide is generally considered safe when taken at recommended doses.

However, taking too much nicotinamide can cause side effects such as nausea, vomiting, diarrhea, headache, and dizziness. If you experience any of these side effects after taking a nicotinamide supplement, stop taking the supplement and speak to your healthcare provider.

If you think you have overdosed on nicotinamide, seek medical attention immediately.

What Are the Precautions of Nicotinamide?

Nicotinamide is generally considered safe when taken at recommended doses. However, there are a few precautions to be aware of before taking nicotinamide.

Nicotinamide may interact with certain medications or supplements. Be sure to speak to your healthcare provider before starting any new supplements, especially if you are taking any medications.

If you have liver disease or are taking medications that can damage the liver, be sure to speak to your healthcare provider before taking nicotinamide. Nicotinamide may also worsen symptoms of peptic ulcers.

If you are pregnant or breastfeeding, be sure to speak to your healthcare provider before taking nicotinamide. Nicotinamide is not recommended for use in children.

Nicotinamide supplements are available for purchase online and at many health food stores and pharmacies. Be sure to speak to your healthcare provider before taking any supplements, especially if you have a medical condition or are taking any medications.