Generic Name: Gemfibrozil

Lopid is a prescription drug that belongs to a class of drugs known as fibrates. It’s used to treat high cholesterol and triglyceride levels. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Lopid is available as an oral tablet.

Lopid is also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Gemfibrozil is used along with diet and exercise to treat high cholesterol and triglyceride levels in people with pancreatitis. Gemfibrozil may also be used for purposes not listed in this medication guide.

Take this medicine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Use the medicine exactly as directed. for the prescription drug Lopid, used to treat high levels of cholesterol and triglycerides.

By lowering these levels, gemfibrozil reduces the risk of heart disease.

Gemfibrozil works by reducing the production of cholesterol in the liver and by increasing the removal of cholesterol from the blood by the liver.

Pfizer manufactures gemfibrozil as the brand-name drug Lopid.

Gemfibrozil may also be used for purposes not listed in this medication guide.

You should not take gemfibrozil if you have severe kidney disease, gallbladder disease, or diabetes.

Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Drug Interactions

Gemfibrozil can interact with other drugs and medications. Tell your doctor about all the prescription and over-the-counter medications you take. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Do not take gemfibrozil with cholesterol-lowering medications called statins, such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor).

Do not take gemfibrozil with other fibrates, such as bezafibrate (Bezalip), fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide), or triglycerides (Lopid).

Do not take gemfibrozil with medications that contain gemfibrozil.

Pharmacokinetics

Gemfibrozil is rapidly absorbed from the gastrointestinal tract and nearly completely metabolized in the liver to two active metabolites, gemfibrozil aldehyde, and hydroxymethylglutaryl-CoA lyase inhibitors. The pharmacokinetics of gemfibrozil is similar whether given as a single or divided dose.

How Should I Take Gemfibrozil?

Gemfibrozil should be taken orally with breakfast or the first main meal of the day.

The usual starting dose is 600 mg twice daily. Depending on your response to treatment, your doctor may adjust your dose up to 900 mg three times daily.

Do not take more or less of this drug than prescribed by your doctor.

Do not stop taking gemfibrozil without talking to your doctor.

Side Effects

The most common side effects of gemfibrozil include:

  • upset stomach
  • nausea
  • vomiting
  • diarrhea
  • constipation
  • heartburn
  • gas
  • headache
  • muscle pain or weakness.

Less common side effects of gemfibrozil include changes in taste, runny nose, sneezing, cough, skin rash, itching, hives, difficulty breathing or swallowing, and swelling of the face, throat, tongue, lips, eyes, hands feet ankles, or lower legs. If you develop any of these symptoms call your doctor immediately. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • upper stomach pain (that may spread to your back), nausea and vomiting;
  • jaundice (yellowing of the skin or eyes);
  • dark urine, clay-colored stools;
  • loss of appetite, weight loss;
  • fever, chills, body aches, flu symptoms;
  • numbness or tingling in your hands or feet;
  • muscle pain or weakness with fever or flu symptoms and dark-colored urine.

Gemfibrozil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Dosage and Administration

The usual starting dose of gemfibrozil is 600 mg twice daily. Depending on your response to treatment, your doctor may adjust your dose up to 900 mg three times daily.

Do not take more or less of this drug than prescribed by your doctor.

Do not stop taking gemfidrozil without talking to your doctor.

If you miss a dose of gemfibrozil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Overdose

An overdose of gemfibrozil may be fatal. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 999. Otherwise, call a poison control center right away.

Storage

Store at room temperature away from heat, moisture, and light. Do not store in the bathroom. Keep gemfibrozil out of the reach of children and away from pets.