Generic name: Paliperidone
Brand names: Invega, Invega Sustenna, Xeplion
Invega (paliperidone) is an antipsychotic medication. It works by helping to restore the balance of certain natural chemicals in the brain. Invega is used to treat schizophrenia and schizoaffective disorder. This medicine should not be used to treat behavior problems in older adults who have dementia.
Some people using this medicine have engaged in activity such as driving, eating, or having sex and later having no memory of the event. If this happens to you, stop taking Invega and talk with your doctor about other treatments for your condition.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Paliperidone is an antipsychotic medicine. It works by changing the effects of chemicals in the brain.
Paliperidone is used to treat schizophrenia in adults and teenagers who are at least 13 years old.
Paliperidone is also used to treat episodes of mania or mixed episodes in adults and teenagers who are at least 18 years old.
Serious side effects may be more likely in older adults and those who are overweight.
Paliperidone may increase the amount of a certain hormone (prolactin) in your blood. Symptoms include enlarged breasts or decreased sexual ability in men. Women may experience irregular menstrual periods and increased discharge from their vagina. Call your doctor if you have any of these symptoms.
Common side effects may include:
- feeling restless or jittery
- upset stomach
- sleep problems (insomnia)
- weight gain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Invega can interact with other drugs, including:
antidepressants; antipsychotics; birth control pills, patches, rings, implants, and injections; blood thinners; heart rhythm medications; seizure medications; or medicine to treat Parkinson’s disease or Alzheimer’s disease. Tell your doctor about all your current medicines and any you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Precautions and Warnings
You should not use Invega if you are allergic to it, or if you have:
a history of stroke or blood clot; or
dementia and you are also taking medicine to treat this condition.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
liver disease; kidney disease; heart disease, congestive heart failure; diabetes (your doctor will monitor your blood sugar level); a thyroid disorder; seizures; long QT syndrome (in you or a family member); problems with electrical activity in your heart (QT prolongation); low levels of potassium in your blood; high prolactin levels; or if you smoke.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using Invega. This medicine can pass into breast milk and may cause side effects in the nursing baby. Tell your doctor if you are breast-feeding a baby.
The Invega brand of paliperidone is not for use in children. The Invegaxr extended-release injectable suspension is for use only in adults and should not be given to a child without medical advice.
Do not give this medicine to anyone under 18 years old without medical advice.
Dosage and Administration
Invega is usually taken once daily with or without food. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose to make sure you get the best results from this medicine. Use the medicine exactly as directed.
Do not take this medicine in larger or smaller amounts or for longer than recommended.
To take Invega tablets:
Swallow the tablet whole with a full glass of water. Do not split, chew, crush, or dissolve the tablet before swallowing it.
If you cannot swallow a tablet whole, ask your doctor about other forms of Invega that may be easier for you to take.
Invega Sustenna is an extended-release injectable suspension. It is usually given once every 4 weeks as an injection into a muscle by a healthcare professional.
If you receive your first dose of Invega Sustenna from a doctor or other healthcare provider, they will teach you how to prepare and give this medicine yourself. You should feel comfortable doing this so that you can treat yourself at home if needed. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of needles, IV tubing, and other items used to inject the medicine.
Call your doctor if your symptoms do not improve, or if they get worse while using Invega.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Invega is not expected to be dangerous.
If you forget a dose of Invega, take it as soon as you remember. You can take it with or without food. Do not take two doses of Invega at the same time to make up for a missed dose.
If you inject this medicine at home and you miss a dose, call your doctor for instructions on what to do.
Note: Do not share this medicine with anyone else, even if they have the same symptoms you have.