PDR Health

Chondroitin Sulfate

What is Chondroitin Sulfate?

Chondroitin sulfate is a natural substance that is found in the connective tissues of humans and animals. It is a major component of cartilage, and it helps to keep joints healthy by providing cushioning and lubrication. Chondroitin sulfate is also found in other tissues such as bone, skin, and tendons.

Chondroitin sulfate is sometimes used as a supplement to treat osteoarthritis, a condition that causes pain and stiffness in the joints. Chondroitin sulfate may help to relieve symptoms of osteoarthritis by reducing inflammation and improving joint function. Some research suggests that chondroitin sulfate may also help to prevent osteoarthritis from getting worse.

Chondroitin sulfate is available as a supplement in many different forms, including capsules, tablets, liquids, and powders. It can also be injected into the joints by a healthcare provider.


The recommended dosage of chondroitin sulfate varies depending on the condition being treated. For osteoarthritis, the typical dosage is 400-800 mg per day. Chondroitin sulfate is often taken together with another supplement called glucosamine.

Possible Side Effects

Chondroitin sulfate is generally considered safe for most people. Some people may experience side effects such as upset stomach, diarrhea, or constipation. Chondroitin sulfate can also cause skin reactions in some people. If you experience any adverse effects after taking chondroitin sulfate, stop taking the supplement and talk to your healthcare provider.

Mechanism of Action

The exact mechanism of action of chondroitin sulfate is not fully understood. It is thought to work by inhibiting the breakdown of cartilage, as well as by reducing inflammation. Chondroitin sulfate may also help to improve joint function by stimulating the production of new cartilage.

Pregnancy and Breastfeeding

Chondroitin sulfate is not recommended for use during pregnancy or breastfeeding due to a lack of safety data. If you are pregnant or breastfeeding, talk to your healthcare provider before taking chondroitin sulfate.


There is no known antidote for chondroitin sulfate overdosage. If you think you have taken too much of this supplement, contact a poison control center or emergency room immediately.


Chondroitin sulfate may interact with certain medications, such as blood thinners and non-steroidal anti-inflammatory drugs (NSAIDs). If you take any medications, it is important to talk to your healthcare provider before taking chondroitin sulfate.


Chondroitin sulfate is not recommended for people with bleeding disorders or those taking blood thinners. Chondroitin sulfate may also not be suitable for people with kidney disease. If you have any concerns about taking chondroitin sulfate, talk to your healthcare provider.