Generic name: caffeine/ergotamine

Manufacturer: Novartis, Pfizer, Sandoz

Cafergot is a medication used to treat migraines. It is a combination of caffeine and ergotamine, which works by narrowing blood vessels around the brain. This helps to relieve the pain of migraines. Cafergot may also be used to treat other conditions as determined by your doctor.

Caffeine is a stimulant that helps to increase alertness and wakefulness. It works by blocking the action of adenosine, a chemical that promotes sleepiness. Ergotamine is a vasoconstrictor that works by narrowing blood vessels. This helps to relieve the pain of migraines.

Cafergot is available in tablet form. It is typically taken three times a day for the treatment of migraines. For the prevention of migraines, it is generally taken two times a day.

Pharmacokinetics

Cafergot is rapidly absorbed from the gastrointestinal tract. peak plasma concentrations of caffeine are reached within 30-60 minutes, while those of ergotamine take 1-2 hours. The elimination half-lives of caffeine and ergotamine are 3-4 and 24 hours respectively.

Cafergot is metabolised in the liver by cytochrome P450 enzymes. The metabolites of cafegot are excreted mainly in the urine.

Side effects

The most common side effects of cafegot are nausea, vomiting, diarrhoea, and abdominal pain. Other side effects include dizziness, drowsiness, headache, and fatigue. cafegot can also cause severe side effects such as liver damage, seizures, and heart problems.

If you experience any of the above side effects, you should stop taking cafegot and seek medical attention immediately.

Cautions

  • Cafergot should not be taken if you are pregnant or breastfeeding. It is also not recommended for children under the age of 12.
  • Cafergot can interact with a number of other medications. Therefore, you should tell your doctor about all the medications you are taking, including over-the-counter medications and supplements.
  • Cafergot can cause dizziness and drowsiness. Therefore, you should not drive or operate machinery until you know how it affects you.
  • Cafergot can also cause birth defects. Therefore, it is important to use contraception if you are taking cafegot and you are of childbearing age.

Dosage and Administration

The usual dose of cafegot for the treatment of migraines is one or two tablets every four hours, up to a maximum of six tablets in 24 hours. For the prevention of migraines, the usual dose is one tablet two times a day.

Cafergot should be taken at the first sign of a migraine headache. It can be taken with or without food.

Overdose

An overdose of cafegot can be fatal. Symptoms of an overdose include nausea, vomiting, diarrhoea, abdominal pain, dizziness, drowsiness, headache, and fatigue. If you experience any of these symptoms, you should seek medical attention immediately.

An overdose of cafegot can also cause liver damage, seizures, and heart problems. If you experience any of these symptoms, you should seek medical attention immediately.

Storage

Cafergot should be stored at room temperature, in a cool, dry place. It should be kept out of the reach of children and pets.

Disposal

If you no longer need cafegot or if it has expired, you should dispose of it safely. You can take it to a pharmacy for safe disposal, or you can dispose of it yourself.

If you dispose of it yourself, you should mix it with an unpalatable substance such as coffee grounds or kitty litter. You should then put it in a sealed container, such as a zip-top bag, and throw it away in the trash.