Generic Name: Bumetanide

Bumex is a medication used to treat edema or fluid retention. It is also used to treat high blood pressure. Bumex belongs to a class of drugs called diuretics. It works by causing your body to get rid of extra water and salt.

Bumex is available in generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug. Bumex may also be used for purposes not listed in this medication guide.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medicine.

FDA pregnancy category C. It is not known whether bumetanide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Bumetanide can pass into breast milk and may harm a nursing baby. You should not breastfeed while you are using bumetanide.

Do not give this medication to a child without medical advice. If you use this medicine long-term, you may need frequent medical tests at your doctor’s office. Your kidney function and electrolyte levels may also need to be checked. Visit your doctor regularly.

Drug Interactions

Bumetanide can interact with other medications, herbs, or vitamins you might be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, herbs, and vitamins you are taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with bumetanide are listed below.

ACE inhibitors such as lisinopril (Zestril), captopril (Capoten), enalapril (Vasotec), and others

NSAIDs such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren, Cataflam), celecoxib (Celebrex), indomethacin (Indocin), and others

This is not a complete list of bumetanide drug interactions. Ask your doctor or pharmacist for more information.

Pharmacokinetics

Absorption

Bioavailability: IV: 100%

Metabolism

Hepatic via CYP450 enzymes to inactive metabolites.

Elimination

Half-life: 1.5–2 hours

It is a prescription medication that is not available over the counter. Bumetanide works by causing the body to get rid of extra water and salt through urine. This helps to lower blood pressure and reduce swelling. Bumetanide is usually taken once or twice a day, depending on the prescribed dose.

Bumetanide is a prescription medication that is not available over the counter. Bumetanide works by causing the body to get rid of extra water and salt through urine. This helps to lower blood pressure and reduce swelling. Bumetanide is usually taken once or twice a day, depending on the prescribed dose. If you experience any serious side effects, call your doctor right away.

Side Effects

The most common side effects of bumetanide include diarrhea, dizziness, and muscle cramps. These side effects are usually mild and do not require medical treatment. Serious side effects of bumetanide include allergic reactions, kidney problems, and liver problems.

Allergic reactions: Bumetanide can cause a severe allergic reaction. Symptoms of a severe allergic reaction include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. If you experience any of these symptoms, stop taking bumetanide and call your doctor right away.

Kidney problems: Bumetanide can cause kidney problems. Symptoms of kidney problems include a decrease in the amount of urine produced, blood in the urine, and swelling in the ankles or feet.

Liver problems: Bumetanide can cause liver problems. Symptoms of liver problems include yellowing of the skin or eyes, dark urine, nausea, vomiting, abdominal pain, and fatigue. Your doctor may need to reduce your dose or stop your treatment with bumetanide.

Dosage and Administration

The recommended starting dose of bumetanide for adults is 0.5 mg to 1 mg once or twice daily. The maximum recommended dose is 10 mg per day. The starting dose for children 6 to 18 years old is 0.1 mg/kg once or twice daily. The maximum recommended dose for children is 2 mg per day.

For people with high blood pressure, the recommended starting dose is 1 mg once or twice daily. The maximum recommended dose is 10 mg per day.

For people with edema, the recommended starting dose is 0.5 mg to 1 mg once or twice daily. The maximum recommended dose is 10 mg per day.

If you miss a dose of bumetanide, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue on your regular dosing schedule. Do not take two doses of bumetanide at the same time.

Overdose

If you take too much bumetanide, call your doctor or poison control center right away. Symptoms of an overdose include low blood pressure, irregular heartbeat, and fainting.

Storage

Bumetanide should be stored at room temperature, away from light and moisture. Do not store it in the bathroom. Keep bumetanide out of the reach of children and pets.