Other names: Beta-Hydroxy-Beta-Methylbutyrate

Drug class: Amino acid; Nutrition supplement

Pregnancy category: C (Risk cannot be ruled out)

Also searches as Branched chain amino acids, BCAAs, leucine, protein synthesis, muscle breakdown

Beta-Hydroxy-Beta-Methylbutyrate (HMB) is a natural metabolite of the amino acid leucine. HMB is thought to work by decreasing protein breakdown and increasing protein synthesis in muscles.

HMB is often sold as a dietary supplement for bodybuilding and strength training. However, there is limited scientific evidence to support these uses.

Some research suggests that HMB may help increase muscle mass and strength in people who are new to weightlifting. However, other studies have found no benefits of HMB supplementation in experienced weightlifters.

HMB is generally considered safe when taken as directed. However, it can cause some side effects, such as nausea, diarrhea, and abdominal pain.

Benefits of HMB supplementation are still unclear. More research is needed to determine if HMB is effective for increasing muscle mass and strength. Until then, HMB supplements are not recommended for healthy adults who are already meeting their protein needs.

Side effects:

abdominal pain

nausea

diarrhea

vomiting

loss of appetite

headache

muscle cramps

fatigue

These side effects are usually mild and go away on their own. If you experience any severe side effects, stop taking HMB and see your doctor.

You should also talk to your doctor before taking HMB if you have any medical conditions or are taking any medications, as HMB may interact with some drugs. Pregnant and breastfeeding women should also avoid taking HMB supplements.

Interaction with Medications

HMB may interact with certain medications.

Some research suggests that HMB may increase the effects of leucine on protein synthesis. Therefore, taking HMB along with leucine could increase the risk of side effects.

HMB may also interact with other amino acids, such as branched-chain amino acids (BCAAs). BCAAs are often taken by bodybuilders and athletes to increase muscle mass and strength. Taking HMB along with BCAA supplements could potentially increase the risk of side effects.

Dosage

The recommended dosage of HMB is 3-6 grams per day. It is best to take HMB supplements with food to reduce the risk of side effects.

HMB supplements are not recommended for pregnant or breastfeeding women.

Where to buy

HMB supplements are available for purchase online and in some health food stores. However, it is important to talk to your doctor before taking any dietary supplements.

Takeaway

HMB is a natural metabolite of the amino acid leucine. It is often sold as a dietary supplement for bodybuilding and strength training, but there is limited scientific evidence to support these uses. Some research suggests that HMB may help increase muscle mass and strength in people who are new to weightlifting, but more research is needed. HMB is generally considered safe when taken as directed, but it can cause some side effects. Pregnant and breastfeeding women should avoid taking HMB supplements. Talk to your doctor before taking HMB if you have any medical conditions or are taking any medications, as HMB may interact with some drugs.

Pharmacokinetics

HMB is rapidly absorbed from the gut and reaches peak plasma concentrations within 1-3 hours. The half-life of HMB is approximately 2-6 hours.

METABOLISM

HMB is metabolized in the liver by beta-oxidation to form CO2 and acetoacetate. Acetoacetate can then be converted to beta-hydroxybutyrate.

elimination

HMB is eliminated in the urine as beta-hydroxybutyrate.

TOXICOLOGY

No data are available on the toxicology of HMB. However, it is considered to be low risk when taken as directed.

Precautions

HMB supplements are not recommended for pregnant or breastfeeding women. Talk to your doctor before taking HMB if you have any medical conditions or are taking any medications, as HMB may interact with some drugs.

  1. Do not take HMB if you are allergic to beta-hydroxybutyrate or leucine.
  2. Do not take HMB if you are pregnant or breastfeeding.
  3. Do not take HMB if you have any medical conditions, such as kidney disease, liver disease, or diabetes.
  4. Do not take HMB if you are taking any medications, such as leucine supplements, branched-chain amino acids (BCAAs), or blood thinners.