Generic name: Moxifloxacin hydrochloride

Drug class: Fluoroquinolone antibiotic

Brand name:

Avelox is the brand name for moxifloxacin, an antibiotic used to treat bacterial infections. Avelox belongs to a class of antibiotics called fluoroquinolones. Other members of this class include ciprofloxacin (Cipro), levofloxacin (Levaquin), and ofloxacin (Floxin). Avelox was approved by the FDA in 1999.

Avelox is an antibiotic that is used to treat a variety of bacterial infections. It is a member of the quinolone class of antibiotics, which are drugs that work by inhibiting the activity of enzymes involved in DNA replication. Avelox is effective against a wide range of bacteria, including those that cause respiratory tract infections, skin infections, and urinary tract infections. It is also sometimes used to treat tuberculosis.

If you are prescribed Avelox for an infection, it is important that you take the entire course of the drug as directed by your doctor. Even if your symptoms improve, you may still have bacteria present in your body that could cause the infection to come back. If you stop taking Avelox before the course of treatment is complete, the bacteria may become resistant to the antibiotic and difficult to treat in the future.

Avelox is a powerful antibiotic that can be effective against a variety of bacterial infections. However, it is important to use it only as directed by your doctor to avoid potentially serious side effects.

Pharmacokinetics

Avelox is rapidly and completely absorbed following oral administration. The peak plasma concentration is reached within 1-2 hours. Avelox is widely distributed in the body and has been detected in all body tissues and fluids studied including cerebrospinal fluid, saliva, and bronchial secretions. Avelox penetrates well into respiratory secretions with concentrations in sputum similar to those found in serum.

Avelox is primarily eliminated by hepatic metabolism via cytochrome P450 3A4 enzymes with subsequent biliary excretion of metabolites. Approximately 80% of an oral dose of Avelox is recovered in the urine as parent drug or metabolites within 24 hours. The mean elimination half-life of Avelox is 11.1 hours.

Indications and Usage

Avelox is also indicated for the treatment of patients with complicated intra-abdominal infections (cIAI) caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa or Bacteroides fragilis.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Avelox and other antibacterial drugs, Avelox should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Side Effects

The most common side effects of Avelox are nausea, vomiting, diarrhea, and headaches. Other potential side effects include dizziness, lightheadedness, and rare but serious problems such as tendon rupture or allergic reactions. If you experience any severe side effects while taking Avelox, you should stop taking the drug and seek medical attention immediately.

Avelox may also interact with other medications. Be sure to tell your doctor about all the drugs you take, including prescription and over-the-counter medications, vitamins, and herbal supplements.

Dosage and Administration

The recommended dosage of Avelox for the treatment of patients with pneumonia is 400 mg once daily for 7 days. For the treatment of patients with acute bacterial sinusitis, the recommended dosage is 400 mg once daily for 10 days.

For the treatment of patients with skin and skin structure infections, the recommended dosage is 400 mg once daily for 7-14 days. For the treatment of patients with cIAI, the recommended dosage is 400 mg once daily for 5-9 days.

Avelox should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. To avoid gastrointestinal side effects, it is important to take Avelox exactly as prescribed by your doctor. Do not skip doses or stop taking Avelox early unless directed to do so by your doctor.

Missed dose

If you miss a dose of Avelox, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Avelox at the same time.

Storage

Avelox should be stored at room temperature, between 68°F and 77°F (20°C and 25°C). Keep Avelox and all medications out of the reach of children.