PDR Health



Aplenzin (bupropion hydrochloride extended-release tablets) is an antidepressant used to treat major depressive disorder and seasonal affective disorder.

Side Effects

Common side effects of Aplenzin include:

nausea, headache, drowsiness, tired feeling, dry mouth, constipation, weight loss, or

changes in taste.

Aplenzin may also cause serious side effects including:

seizures (convulsions), changes in thinking or behavior (suicidal thoughts or actions),


nervous system problems (anxiety, agitation, panic attacks, insomnia, abnormal dreams,

tremors, tingling or numbness of the skin).


Aplenzin is available in strengths of 18 mg, 36 mg, and 72 mg extended-release tablets.

The recommended starting dose is 174 mg/day, given as a single daily dose in the morning.

Patients should be monitored for response and toxicity.

How Aplenzin works

Aplenzin is an antidepressant medication that works in the brain.

It is thought to work by increasing the levels of norepinephrine and dopamine,

two neurotransmitters that help regulate mood.


Before taking Aplenzin, tell your doctor or pharmacist if you are allergic to it;

or if you have any other allergies. Aplenzin may contain inactive ingredients,

which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Do not use Aplenzin if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

You should not take Aplenzin if you are pregnant or breast-feeding.