Antivert (meclizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antivert is used to treat motion sickness and dizziness associated with inner ear problems (vertigo). Antivert may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not take Antivert if you are allergic to meclizine. To make sure Antivert is safe for you, tell your doctor if you have any of these conditions: asthma; epilepsy or other seizure disorder; glaucoma; kidney disease; liver disease; urination problems. It is not known whether Antivert will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether meclizine passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor’s advice if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine. Do not give this medication to a child without medical advice. Your dose needs may be different during pregnancy. Do not take this medicine in larger or smaller amounts or for longer than recommended. Do not take more of this medication than your doctor has prescribed. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. To take Antivert: Take the tablet with a full glass of water. Swallow the capsule whole and do not crush, chew, break, or open it. To prevent motion sickness: Start taking the medicine 1 to 2 hours before you travel or anticipate having these symptoms. For best results, keep taking the medicine as directed by your doctor or package instructions.

Benefits of Antivert

Antivert can be used to treat motion sickness and dizziness, as well as vertigo associated with inner ear problems. Additionally, Antivert may also be effective in treating other conditions not listed on the medication guide. Some of the benefits of taking Antivert include:

-Reduced symptoms of sneezing, itching, watery eyes, and runny nose

-Treatment of motion sickness and dizziness

-Relief from vertigo associated with inner ear problems

Side effects of Antivert may include:

-Drowsiness

-Headache

-Nausea

-Vomiting

-Dry mouth

-Constipation

-Blurred vision

Pharmacokinetics

The pharmacokinetics of meclizine have not been investigated in human studies.

A study in rats, however, has shown that meclizine is rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-2 hours after oral administration. Meclizine is widely distributed in the body, with levels in the brain being particularly high. The elimination half-life of meclizine is about 12 hours. Meclizine is eliminated primarily by hepatic metabolism, with only a small amount (10%) excreted unchanged in the urine.

The pharmacokinetics of meclizine are not well understood. The drug is thought to be metabolized in the liver, and the metabolites are excreted in the urine. The half-life of meclizine is about 2 to 3 hours.

Interaction

Antivert may interact with other medications. Consult your doctor or pharmacist for more information. If you do not have a dose-measuring device, ask your pharmacist for one.