Brand Names

  • Auralgan Otic
  • Cerumenex
  • Otic Relief
  • Preparation H Ear Drops
  • Tisit Ear Drops

Generic name: The generic name for A&B is antipyrine and benzocaine ear drops.

Antipyrine and benzocaine (A&B) is a topical medication used to relieve pain and itching caused by ear infections. It is available over-the-counter (OTC) in most countries.

A&B works by numbing the affected area and prevents the spread of infection. It is typically used for temporary relief of pain and discomfort associated with ear infections, such as swimmer’s ear.

If you are using A&B for the first time, it is important to follow the instructions on the package insert carefully. In general, A&B should only be used for short-term relief of symptoms and should not be used on open wounds or broken skin.

It is also important to note that A&B is not a cure for ear infections and will not prevent them from recurring. If your symptoms persist or worsen, you should see your doctor for further evaluation.


Antipyrine has a half-life of 3.8 hours in adults and 5.4 hours in children. Benzocaine has a half-life of 2.7 hours in adults and 3.4 hours in children.

The elimination of antipyrine is primarily through the kidneys, while benzocaine is eliminated through both the kidneys and liver.

Side Effects

The most common side effect of A&B is mild irritation at the site of application. This is typically not a serious concern and usually goes away on its own with continued use.

Other potential side effects include:

Allergic reactions (rash, hives, itching, difficulty breathing)

  • Nausea and vomiting
  • Diarrhea
  • Dizziness or lightheadedness

If you experience any of these side effects, stop using A&B and see your doctor right away. Serious allergic reactions to A&B are rare but can be life-threatening. If you have a history of allergies or asthma, you may be at increased risk for an allergic reaction to A&B.


A&B is generally safe for most people when used as directed. However, there are some risks to be aware of.

Do not use A&B if you are allergic to antipyrine, benzocaine, or any other ingredient in the medication.

Do not use A&B on open wounds or broken skin. This could increase your risk for an infection or other complications.

Do not use A&B if you are pregnant or breastfeeding unless directed by your doctor. It is not known if the medication can pass into breast milk and cause harm to a nursing baby.

If you have any other medical conditions, such as kidney or liver disease, discuss with your doctor whether A&B is safe for you to use.

A&B is not recommended for use in children under the age of 2 years unless directed by a doctor. The safety and effectiveness of the medication has not been established in this age group.


There are no known drug interactions with A&B. However, as with all medications, it is always best to check with your doctor or pharmacist before starting any new medication, even OTC products.

Dosage and Administration

The recommended dose of A&B for ear pain relief is 5-10 drops placed into the affected ear 4 times daily for 7 days. For itching, the recommended dose is 2-4 drops placed into the affected ear as needed for up to 48 hours.

Do not use A&B more often or for longer than recommended by your doctor. This could increase your risk for side effects or make your symptoms worse.

It is also important to shake the bottle well before use. To apply the ear drops, tilt your head to the side and gently pull back on your earlobe. Place the recommended number of drops into the ear canal and then remain tilted for at least 1 minute to allow the medication to be absorbed.

To prevent contamination, do not touch the tip of the dropper to any surface, including your ear. After use, be sure to recap the bottle tightly and store it out of reach of children.

If you have any questions about how to use A&B, talk to your doctor or pharmacist.


If you think you have used too much of this medicine, contact a poison control center or emergency room at once. Symptoms of an overdose may include:

  • Dizziness or lightheadedness
  • Nausea and vomiting
  • Diarrhea
  • Allergic reactions (rash, hives, itching, difficulty breathing)

If you experience any of these symptoms, stop using A&B and see your doctor right away. An overdose of A&B is not typically life-threatening but can cause serious side effects. Never share A&B with another person, especially someone who has a history of allergies or asthma.

Missed Dose

If you miss a dose of A&B, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use two doses of A&B at the same time.


Store A&B at room temperature away from light and moisture. Do not freeze. Keep the bottle tightly closed when not in use. Do not store A&B in the bathroom or near any other source of heat or moisture. Discard any unused portion after 7 days.