Generic name: flurbiprofen

Brand names: Ansaid, Ansaid Ophthalmic, Fluorbital, Flurbiprofen Axetil, Flurbiprofen Sodium

Ansaid (flurbiprofen) is a nonsteroidal anti-inflammatory drug (NSAID). Flurbiprofen works by reducing hormones that cause inflammation and pain in the body. Ansaid is used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. Ansaid may also be used for purposes not listed in this medication guide. You should not use Ansaid if you are allergic to flurbiprofen or any other NSAID (naproxen, ibuprofen, celecoxib, diclofenac, indomethacin, meloxicam, and others).

To make sure Ansaid is safe for you, tell your doctor if you have ever had:

  • kidney disease
  • liver disease
  • high blood pressure, heart disease, or congestive heart failure
  • asthma or other breathing disorder
  • swelling or fluid retention
  • a bleeding or blood clotting disorder
  • stomach ulcers
  • ulcerative colitis
  • Crohn’s disease

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. If you take Ansaid on a regular basis, your doctor will want to check your progress at regular visits. Your blood and urine may be tested to check for unwanted effects. Do not take two doses of Ansaid at the same time. Overdose symptoms may include drowsiness, shallow breathing, slow heartbeat, fainting, or seizure (convulsions).

Ansaid

Pharmacokinetics

Ansaid is rapidly absorbed from the gastrointestinal tract with peak plasma concentrations occurring 1 to 2 hours after administration. The bioavailability of Ansaid is approximately 100%.

The plasma protein binding of Ansaid is 99%, primarily to albumin.

flurbiprofen is metabolized in the liver by cytochrome P450 enzymes, primarily by CYP2C9, to several metabolites, the major ones being 5-hydroxyflurbiprofen and 3′-hydroxyflurbiprofen.

The elimination half-life of flurbiprofen ranges from 1.3 to 4 hours.

Ansaid is excreted in the urine as metabolites and conjugates. Less than 1% of the administered dose is recovered in the urine as unchanged flurbiprofen.

Side Effects

Side effects of Ansaid may include:

  • stomach pain, heartburn, gas, bloating, constipation, or diarrhea
  • dizziness, drowsiness, headache, nervousness
  • blurred vision
  • ringing in your ears
  • swelling in your hands or feet
  • white patches or sores inside your mouth or on your lips
  • skin rash or itching.

Call your doctor at once if you have:

  • shortness of breath (even with mild exertion), swelling, rapid weight gain
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes)
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • bruising, severe tingling, numbness, pain, muscle weakness
  • 2 or more gout attacks in a row
  • the first signs of skin rash such as itching, red, swollen, blistered, or peeling skin with or without fever
  • signs of stomach bleeding–severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

DOSAGE AND ADMINISTRATION

The recommended dosage range for Ansaid Tablets is 100 to 200 mg daily. Patients should receive the minimum effective dosage for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

If stomach upset occurs, take with food or milk.

For the relief of rheumatoid arthritis, the usual adult dosage is 100 to 200 mg daily in divided doses.

For the relief of osteoarthritis, the usual adult dosage is 100 to 200 mg daily in divided doses.

For the relief of menstrual cramps, the usual adult dosage is 50 to 100 mg daily.

Indications and Usage

Ansaid is indicated for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.

Overdose

Overdose of Ansaid is unlikely to produce life threatening symptoms. In case of overdosage, discontinue medication, treat symptomatically and institute supportive measures. Fluid and electrolyte balance should be monitored.

Storage

Store at 20°-25°C (68°-77°F) See USP Controlled Room Temperature.] Protect from moisture. Dispense in a tight, light-resistant container as defined in the USP/NF.