Generic name: fluticasone and salmeterol

Drug class: Long-Acting Beta2-Agonists; corticosteroids, inhalation

Advair Diskus is a prescription medication used to treat asthma and COPD. It is a combination of two drugs, fluticasone and salmeterol, that work together to help prevent asthma attacks and improve lung function. Advair Diskus is available in two strengths: 50/250 mcg and 500/50 mcg. It is taken twice daily, with the first dose in the morning and the second dose in the evening.

Advair Diskus

Pharmacokinetics

Pharmacokinetics is the study of how a drug is absorbed, distributed, metabolized, and eliminated by the body. Advair Diskus is a combination of two drugs, fluticasone and salmeterol. Fluticasone is a corticosteroid that reduces inflammation in the lungs. Salmeterol is a beta-adrenergic agonist that relaxes the muscles around the airways. Both drugs are inhaled through the mouth using an inhaler device. The drugs are then absorbed into the bloodstream through the lungs. They are both metabolized by the liver and excreted by the kidneys. The half-life of fluticasone is about 9 hours and the half-life of salmeterol is about 12 hours. This means that it takes about 9 hours for half of the fluticasone to be eliminated from the body and 12 hours for half of the salmeterol to be eliminated.

Drug Interactions

Advair Diskus can interact with other drugs, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with Advair Diskus are listed below.

Interactions with other drugs

Fluticasone and salmeterol can interact with other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Do not take Advair Diskus if you are taking a monoamine oxidase inhibitor (MAOI). MAOIs include isocarboxazid, linezolid, methylene blue, phenelzine, rasagiline, selegiline, and tranylcypromine.

Interactions with other substances

Advair Diskus can interact with other substances, such as alcohol or tobacco. Smoking can decrease the effectiveness of fluticasone and increase the risk of side effects. If you smoke tobacco, ask your doctor about ways to help you quit.

Side Effects

Advair Diskus can cause serious side effects, including:

  • headache
  • dizziness
  • nervousness
  • shaking hands that you cannot control
  • increased blood pressure
  • fast or irregular heartbeat
  • chest pain or tightness
  • trouble breathing
  • wheezing
  • coughing up blood or vomit that looks like coffee grounds

Seek medical attention right away if you have any of these symptoms. Advair Diskus can also cause less serious side effects, such as runny nose sore throat mild headache muscle pain upset stomach diarrhea vomiting coughing

Precautions and Warnings

Advair Diskus should not be used by people with certain medical conditions, such as heart disease or high blood pressure. It can also cause side effects, such as headaches, dizziness, and upset stomach. If you experience any serious side effects, seek medical attention immediately. Talk to your doctor about whether Advair Diskus is right for you.

The FDA has issued a black box warning for Advair Diskus and other similar medications. A black box warning is the most serious type of warning from the FDA. It means that there is a serious risk of adverse effects, including death. The FDA warns that Advair Diskus and other similar medications should not be used by people with asthma who are under 4 years old. These medications should also be used with caution in people with COPD who are under 18 years old.

Advair Diskus is a prescription medication. It is not available over-the-counter (OTC). Advair Diskus is a powder that is inhaled using a special inhaler device. The powder is stored in a foil pouch inside the inhaler device. Each time you take a breath, a small amount of powder is released into your mouth. You then inhale the powder into your lungs.

Dosage

The recommended dose of Advair Diskus is one inhalation twice daily. The first dose should be taken in the morning and the second dose should be taken in the evening. Advair Diskus is available in two strengths: 50/250 mcg and 500/50 mcg. The 50/250 mcg strength is for people who are taking other inhaled corticosteroids and beta-adrenergic agonists for asthma. The 500/50 mcg strength is for people who are taking other inhaled corticosteroids for COPD.