What is dimethylglycine?

Dimethylglycine (DMG) is a nutrient that can be found in small amounts in many foods, including beans, grains, and green vegetables. It’s also sold as a dietary supplement.

DMG is sometimes promoted for increasing energy, improving mental function, and boosting the immune system. However, there is no scientific evidence to support these uses.


Health Benefits

DMG is sometimes taken as a dietary supplement for various purported health benefits. However, there is little to no scientific evidence to support most of these uses.

For example, DMG is often claimed to:

1. Boost energy levels

2. Enhance mental function

3. Strengthen the immune system

4. Help with autism and other disorders characterized by social or communication difficulties

5. Reduce inflammation throughout the body

6. fight cancer cells

7. protect against heart disease

8. improve physical performance

Side Effects and Safety Concerns

Dimethylglycine is LIKELY SAFE when taken by mouth in food amounts or when used as a medicine up to 600 mg daily for up to 3 months. It’s also LIKELY SAFE when applied to the skin.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Dimethylglycine is LIKELY SAFE for most adults when taken by mouth in food amounts or when used as a medicine up to 600 mg daily for up to 3 months. But stay on the safe side and avoid use.

Children: Dimethylglycine is LIKELY SAFE for most children when taken by mouth appropriately. Children 2-18 years old can take dimethylglycine 50-200 mg three times per day for up to 3 months.

Allergy to soy: If you are allergic to soy, don’t use dimethylglycine products that contain soy.

Kidney disease: People with kidney disease should avoid using dimethylglycine.

Low blood pressure: Taking dimethylglycine might lower blood pressure. If your blood pressure is already low, taking dimethylglycine might cause it to drop too low.Do not take this product if you are taking medications for blood pressure or heart conditions.

Surgery: Dimethylglycine might slow down the central nervous system. There is a concern that it might interfere with anesthesia during surgery. Stop using dimethylglycine at least 2 weeks before a scheduled surgery.

Dosage and Preparation

There is no general recommended dosage for dimethylglycine. However, some researchers have suggested that taking 50-200 mg three times per day for up to 3 months is safe for most children and adults.

Dimethylglycine is available in supplements, including tablets, capsules, powders, and liquids. It can also be found in some foods, such as beans, grains, and green vegetables.

Some people apply dimethylglycine directly to the skin for wound healing or joint pain.


If you take any medications regularly, talk to your doctor before you start using dimethylglycine. It could interact with medications for high blood pressure, heart conditions, and anesthesia.

Dimethylglycine might also interact with cancer treatments.

Mechanism of Action

It’s unclear how DMG might work in the body. Some researchers believe that it might increase levels of certain chemicals in the brain, including serotonin and glutathione. Serotonin is a neurotransmitter that plays a role in mood and anxiety. Glutathione is an antioxidant that helps protect cells from damage.


DMG is rapidly absorbed from the gut and metabolized in the liver. Less than 1% of a dose of DMG is excreted unchanged in the urine.

Research Evidence

Despite its widespread use, there is little scientific evidence to support the health claims associated with dimethylglycine. Here’s a look at some key findings from the available research on DMG:

1. Autism

A small study published in 2009 found that children with autism who took DMG supplements for six months had improvements in social and communication skills, as well as overall behavior. However, it’s important to note that this study was very small and not well-designed. Larger, better-designed studies are needed to confirm these findings.

2. Cancer

Some preliminary research suggests that DMG might help fight cancer cells. However, these studies are very small and more research is needed before any conclusions can be drawn.

3. Physical performance

A small study published in 2009 found that athletes who took DMG supplements had improved physical performance, but the study was not well-designed. More research is needed to confirm these findings.

4. Heart disease

Some animal studies suggest that DMG might help protect against heart disease, but there is no evidence from human studies to support this claim.

5. Wound healing

A few small studies have found that applying DMG to the skin might promote wound healing, but more research is needed to confirm these finding potency of these products can vary widely from one brand to another.

Alternatives to Dimethylglycine

There are many potential alternative treatments for the conditions that dimethylglycine is used for. Some examples include:

For autism: behavioral therapy, speech therapy, and occupational therapy

For cancer: chemotherapy, radiation therapy, and immunotherapy

For heart disease: lifestyle changes, such as exercise and diet, and medications, such as statins

For wound healing: silver dressings, negative pressure wound therapy, and growth factor therapies