What are Decadron Tablets?

Decadron (dexamethasone) is a corticosteroid that works by reducing inflammation. Decadron Tablets are used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.

Do not take this medication if you are allergic to dexamethasone or any other ingredient in the formulation. Do not take this drug if you have a history of peptic ulcer disease or gastrointestinal bleeding. If you are pregnant or breastfeeding, please consult your healthcare provider before taking this medication.

Health Benefits

Decadron is used to treat a wide variety of medical conditions. It is a potent anti-inflammatory medication that can be used to decrease swelling, redness, and itching caused by various medical conditions such as:

allergic reactions

skin conditions

ulcerative colitis




breathing disorders

Decadron may also be used for purposes not listed in this medication guide.

Side Effects

The most common side effects of Decadron include:

stomach upset






If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Call your doctor right away if you have serious side effects. Call the emergency services if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

adrenal gland problems–loss of appetite, tiredness, weakness, nausea and vomiting, stomach pain, unusual weight loss

eye problems–blurred vision, eye pain or redness, seeing halos around lights

high blood sugar–increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss

low potassium levels–confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort or muscle weakness or limp feeling

signs of a new infection–fever, chills, body aches and pains, flu symptoms

severe mental changes–anxiety, agitation, confusion (can be accompanied by hallucinations), depression , irritability , seeing things or hearing voices that do not exist (psychosis)

signs of Cushing’s syndrome–weight gain (especially in your face and trunk), slow healing of cuts or bruises, thinning skin, acne , purple stretch marks on the skin, increased hair growth, muscle weakness, tiredness, and changes in mood or behavior

signs of low adrenal gland hormone levels–tiredness, weakness, dizziness , nausea and vomiting , headache , loss of appetite , body aches, joint or muscle pain

stomach ulcers–black, tarry stools; vomit that looks like coffee grounds; blood in the stool; weight loss ; severe stomach pain or cramps Seek medical attention immediately if any of these side effects occur.


The dosage of Decadron that your healthcare provider prescribes will vary depending on a number of factors, such as your age, weight, medical history, and the severity of your condition. Do not change your dose or stop taking this medication without first talking to your doctor.

If you miss a dose of Decadron, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Decadron at room temperature away from light and moisture. Do not store in the bathroom. Keep Decadron out of the reach of children and pets.


Decadron may interact with other steroids, insulin or oral diabetes medications, seizure medication, blood thinners, cyclosporine, rifampin, ketoconazole or itraconazole, or HIV/AIDS medicine. Tell your doctor all medications you are taking. Decadron is not recommended for use during pregnancy due to the potential for harm to the fetus. It is unknown if this drug passes into breast milk. Consult your healthcare provider before breastfeeding.

As this eMedTV Web article explains, there are a number of Decadron drug interactions that can occur when it is combined with other medications — such as rifampin and HIV protease inhibitors. This page describes these interactions in detail and explains how they can be avoided.

Mechanism of Action

Decadron is a synthetic adrenocortical steroid with approximately eight times the potency of prednisone. Decadron has significant immunosuppressive and anti-inflammatory effects. The exact mechanism of action is unknown.


Decadron is rapidly absorbed from the gut and undergoes first pass metabolism in the liver. Decadron is widely distributed into body tissues and crosses the blood brain barrier. Decadron is metabolized by the liver to inactive metabolites and is excreted by the kidneys.