What is Cefzil?

Cefzil (cefprozil) is a cephalosporin antibiotic. It works by fighting bacteria in your body.

Cefzil is used to treat many different types of infections caused by bacteria. This medicine will not work for viral infections (such as common cold, flu).


Health Benefits

Cefzil is used to treat bacterial infections in the respiratory tract, skin, and urinary tract. It also treats ear infections.

Cefzil may also be used for purposes not listed in this medication guide.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have: diarrhea that is watery or bloody; stomach pain, cramping; blood in your urine; kidney problems–little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath. Common side effects may include: nausea, vomiting; mild diarrhea; headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.


The recommended adult dose of cefzil ranges from 250 mg to 500 mg twice daily. The usual pediatric dose is 10 mg/kg (up to 500 mg) twice daily.


Cefzil may interact with other medications. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, cefzil should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breast-feeding.

Mechanism of Action

Cefzil works by inhibiting bacterial cell-wall synthesis. This results in the death of the bacteria.


Cefzil is rapidly absorbed following oral administration. The mean peak serum concentration is reached within 1 to 2 hours. Cefzil is widely distributed into tissues and body fluids. Protein binding ranges from 18% to 37%. Cefzil is eliminated primarily by renal excretion as unchanged drug. The half-life of cefzil is approximately 1 to 2 hours in adults with normal renal function.

Long-term effects

Cefzil has not been studied for long-term effects.

Clinical Trials

The safety and effectiveness of cefzil have been established in children aged 3 months and older. The most common side effects seen in children taking cefzil were diarrhea, vomiting, and rash.


Cefzil has been shown in vitro to be active against most strains of the following microorganisms:

Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis.

Cefzil is indicated for the treatment of susceptible strains of the following infections:

Respiratory tract infections including otitis media; skin and skin structure infections; urinary tract infections. Cefzil may also be used for purposes not listed in this guide.

Alternatives to Cefzil

There are many alternatives to cefzil, including other antibiotics. Some of these alternatives include: amoxicillin, azithromycin, erythromycin, levofloxacin, and

trimethoprim/sulfamethoxazole. Talk to your doctor about the best treatment option for you.

Is amoxicillin more effective than cefzil?

There is no definitive answer to this question as different antibiotics work better for different people. You should speak with your doctor to determine if amoxicillin or cefzil is the best option for you.