PDR Health


What is Arimidex?

Arimidex (anastrozole) is a non-steroidal aromatase inhibitor that is used to treat breast cancer in women after menopause. Arimidex works by reducing the amount of estrogen in the body, which helps to decrease the size and growth of breast tumors.Arimidex is usually taken once a day with or without food.


Health Benefits

Arimidex has been shown to be effective in the treatment of breast cancer. In a clinical trial of postmenopausal women with early-stage breast cancer, Arimidex was shown to reduce the risk of the cancer coming back or spreading by 65%. Arimidex also increased the time until the cancer progressed compared to tamoxifen, and resulted in fewer side effects.

Arimidex may also be used to treat other types of hormone-sensitive cancers, such as ovarian cancer, endometrial cancer, and prostate cancer.

Side Effects

The most common side effects of Arimidex include hot flashes, joint pain, fatigue, and nausea. Arimidex may also cause an increase in cholesterol levels. Less common side effects include weight gain, bone pain, depression, and headache.

If you experience any of the following side effects, call your doctor immediately:

– Shortness of breath

– Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or lower legs

– Hives or rash

– itching

– difficulty swallowing or breathing

– hoarseness

Mechanism of Action

Arimidex works by inhibiting the enzyme aromatase, which is responsible for the conversion of testosterone to estrogen. By reducing the amount of estrogen in the body, Arimidex decreases the size and growth of breast tumors.

Dosage and Administration

Arimidex is available in tablets of 0.5 mg and 1 mg. The recommended dose of Arimidex is one tablet taken once a day.

Arimidex may be taken with or without food. If you experience nausea while taking Arimidex, take it with food.

If you miss a dose of Arimidex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue on your regular schedule. Do not take two doses of Arimidex at the same time.


Arimidex may interact with tamoxifen, warfarin, and estrogen-containing medications. Tell your doctor all medications you are taking. Arimidex should not be taken during pregnancy.

Pregnancy and Lactation

Arimidex is not recommended for use during pregnancy. Arimidex may be excreted in breast milk and could cause harm to a nursing infant. If you are pregnant or breastfeeding, talk to your doctor before taking Arimidex.


Arimidex is rapidly absorbed following oral administration. The maximum concentration of Arimidex in the blood is reached within 3-4 hours. Arimidex is widely distributed throughout the body, and is bound to plasma proteins 99%. Arimidex is metabolized in the liver by CYP3A4. The metabolites of Arimidex are excreted in the urine and feces.

Alternatives to Arimidex

Arimidex is the brand name for anastrozole. There are no generic forms of Arimidex currently available.