Accretropin

Generic name: Somatropin

What is Accretropin?

Accretropin is recombinant human growth hormone, somatropin, produced by recombinant DNA technology. It is indicated for the treatment of pediatric patients who have growth failure due to an inadequate secretion of normal endogenous growth hormone, and treatment of short stature associated with Turner syndrome in pediatric patients whose epiphyses are not closed.

What is the most important information I should know about Accretropin?

The safety and effectiveness of Accretropin in adult patients has not been evaluated. It should not be used in children whose epiphyses have been closed, patients with proliferative or preproliferative diabetic retinopathy, in the presence of active cancer, critically ill patients, or patients with Prader-Willi syndrome.

Who should not take Accretropin?

Accretropin should not be used in children whose epiphyses have been closed, patients with proliferative or preproliferative diabetic retinopathy, or in the presence of active cancer. It should not be given to critically ill patients due to complications following open heart surgery, abdominal surgery or multiple accidental trauma, or those with acute respiratory failure. Patients with any evidence of progression or recurrence of an underlying intracranial tumor, or patients with Prader-Willi syndrome should not receive Accretropin.

What should I tell my doctor before I take the first dose of Accretropin?

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Accretropin. Also, talk to your doctor about your complete medical history, especially if you have any preexisting diabetes, brain tumors, or hypothyroidism (a decrease thyroid hormone levels).

What is the usual dosage?

The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

In the patients with growth hormone deficiency, the recommended weekly dose is 0.18-0.3 mg/kg body weight. In patients with Turner syndrome, the recommended weekly dose is 0.36 mg/kg of body weight. The dose should be divided into equal daily doses given 6 or 7 times per week injected subcutaneously (under the skin).

How should I take Accretropin?

Take Accretropin as prescribed by your doctor. It should be injected subcutaneously (under the skin) and never into the vein.

What should I avoid while taking Accretropin?

Avoid missing any appointments with your doctor, since this medication needs to be given on a regular schedule.

What are possible food and drug interactions associated with Accretropin?

No formal drug interaction studies have been conducted.

What are the possible side effects of Accretropin?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: development of antibodies to the protein, tissue atrophy, local or systemic allergic reactions

Can I receive Accretropin if I am pregnant or breastfeeding?

Accretropin should be avoided during pregnancy and breastfeeding. Talk with your doctor before receiving this drug if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Accretropin?

Ask your doctor for advice.

How should I store Accretropin?

Vials of Accretropin should be stored in the refrigerator.